Friday 25 April 2014

115-year-old woman's blood hints at limits to longevity


Credit: Discovery Magazine
Hendrikje van Andel-Schipper (1890-2005) was at one time, the oldest woman in the world.

http://blogs.discovermagazine.com/d-brief/2014/04/24/115-year-old-womans-blood-reveals-limits-on-longevity/#.U1m-pNB_W2c

http://www.newscientist.com/article/dn25458?cmpid=NLC%7CNSNS%7C2014-2404-GLOBAL&utm_medium=NLC&utm_source=NSNS&#.U1m_U9B_W2c / death is the one certainty in life analysis blood old world world's oldest healthiest women clues 1890 Hendrikje van Andel-Schipper oldest woman in the world health crystal clear cognition death blood circulatory system free of disease died 2005 bequeathed her body to science living relatives outcomes of scientific analysis made public researchers examine examined blood tissues affected by age lifespan limited capacity stem cells keep replenishing tissues stem cells reach state of exhaustion imposes a limit on their own lifespan body's capacity body regenerating vital tissues cells blood twilight of her life white blood cells stem cells blood stem cells stem cell divisions limit to human life Henne Holstege VU University Medical Center Amsterdam the Netherlands research team replenishment cells saved from earlier in your life evidence stem cell fatigue observations worn down telomeres telomere chromosomes burn down like wicks each time a cell divides division brain cells replicate life team white blood cell generating stem cells pattern of mutations blood cells cell researchers conclude mother stem cells born 20,000 blood stem cells active to replenish blood telomeres stem cell exhaustion mutations blood cells lifetime somatic mutations studied old healthy person disease cancer suggest repair abort repairing aborting cells dangerous mutations study investigate accumulation somatic mutations tissues old individual Chris Tyler-Smith Wellcome Trust Sanger Institute Hinxton UK germ line mutations birth studies selection somatic mutations cancer Tyler-Smith normal non-cancerous tissues health consequences Holstege results rejuvenating ageing bodies injections stem cells saved birth early life long telomeres genes protect against Alzheimer's disease genome succumb abnormally early disease /

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